Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models.
نویسندگان
چکیده
Zebrafish (Danio rerio) are becoming increasingly popular in neurobehavioral research. Here, we summarize recent data on behavioral responses of adult zebrafish to a wide spectrum of putative anxiolytic and anxiogenic agents. Using the novel tank test as a sensitive and efficient behavioral assay, zebrafish anxiety-like behavior can be bi-directionally modulated by drugs affecting the gamma-aminobutyric acid, monoaminergic, cholinergic, glutamatergic and opioidergic systems. Complementing human and rodent data, zebrafish drug-evoked phenotypes obtained in this test support this species as a useful model for neurobehavioral and psychopharmacological research.
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عنوان ژورنال:
- Progress in neuro-psychopharmacology & biological psychiatry
دوره 35 6 شماره
صفحات -
تاریخ انتشار 2011